JERUSALEM Jerusalem: Israeli researchers and their United States colleagues have developed an antibody-based treatment that enables the body's immune system to effectively attack cancer cells and stop their spread, Israel's Weizmann Institute of Science (WIS) said in a statement on Monday.WIS-led scientists revealed that a form of breast cancer known as triple-negative breast cancer is able to form “molecular bridges” to nearby immune cells. Encourages. These bridges prevent immune cells from attacking the tumor, resulting in immune suppression.
The research team demonstrated that antibody treatment that blocks the formation of these bridges can revive the immune system's ability to mount a stronger attack on cancer cells, thereby halting tumor progression in mouse models. He explained that while breast cancer cells themselves express very low levels of the protein CD84, which is used to form bridges, they induce nearby immune cells to produce larger amounts of this protein. , forming bridges that suppress the immune response.
The study also found that higher levels of CD84 in patients' tumors were associated with shorter survival times. Experiments with genetically engineered mice lacking CD84 revealed smaller tumor growth, revealing how CD84 suppresses T cell activity in the immune system in the tumor environment. Weeks in mice developing breast cancer Administered twice, the antibody significantly slowed tumor growth and, in some cases, led to complete cures.
The team noted that the antibody selectively targets cells with high CD84 levels, sparing healthy immune cells that express this protein at lower levels, Xinhua news agency reported. The researchers suggested that this treatment approach could be applied to different cancer types by focusing on the tumor microenvironment rather than the cancer cells.
Comments are closed.