NEW DELHI New Delhi: US scientists have discovered why obesity increases the risk of type 2 diabetes by targeting fat cells. The study, published in Cell Reports, could lead to new treatments for type 2 diabetes and other chronic diseases. Which work by helping fat stem cells differentiate and make new, smaller fat cells.
For the first time, the team at the University of California-Los Angeles (UCLA) showed that obesity can make it difficult for the body to produce key cellular building blocks called ribosomal factors. Without enough ribosomal factors, fat stem cells cannot produce functioning fat cells. Can do. Their energy gets trapped and increases and plays an important role in the development of diabetes.
While adipose tissue has long been blamed, it “is actually essential for maintaining normal glucose metabolism,” said Dr. Claudio Villanueva, associate professor of integrative biology and physiology at the University of California-Los Angeles. Villanueva explained that people with obesity have “a lot of fat tissue that is not functioning optimally.”
Fat tissue stores energy from food. However, when it does not function properly, excess energy is stored elsewhere in the body such as in the liver – leading to fatty liver disease; or in the heart – leading to atherosclerosis or stroke. The study included obese and diabetic rats. The fat cells of these mice were four to five times larger than the fat cells found in lean mice. The team gave him rosiglitazone.
The results showed that their ribosomal factors increased to normal levels, causing their fat stem cells to begin to differentiate to produce new, smaller fat cells. Additionally, it enabled the mice's fat tissue to function properly in storing energy. They also produce key hormones that regulate metabolism. However, scientists found that although the mice remained obese after taking the drug, their “type 2 diabetes essentially disappeared.”
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