BHU’s new research will save from kidney failure, 95 DNA variants of polycystic kidney disease revealed

New Genome Variants Kidney Disease: Kashi Hindu University (BHU) has once again become the center of discussion across the world in the field of medical research. Scientists of BHU’s Center for Genetic Disorders have made an important achievement regarding Polycystic Kidney Disease (PKD). Researchers have identified 35 percent of new genome variants responsible for this incurable disease. This discovery will not only help in understanding the causes of the disease, but will also pave the way for its accurate treatment in future.

What is Polycystic Kidney Disease (PKD)?

Polycystic kidney disease is a genetic disorder in which many small lumps (cysts) filled with fluid start forming inside the kidneys. As the size and number of these cysts increase, the kidney becomes abnormally sized. This has a direct impact on kidney function, which ultimately leads to kidney failure. According to statistics, it is the main reason behind about 5 percent of kidney failure cases worldwide.

What was revealed in BHU’s research?

Pro. The team of researchers Dr. Sonam Raj, Dr. Chandra Devi and Jitendra Kumar Mishra, led by Parimal Das, conducted an in-depth study of the two main genes responsible for PKD—PKD-1 and PKD-2. A total of 95 DNA variants (mutations) have been identified in the research.

According to the study, 67 variants have been found in the PKD-1 gene and 29 variants in the PKD-2 gene. Of these, 64 percent variants were already known, but 35 percent variants are completely new. Recognizing this important research globally, ‘Elsevier’ and ‘Turkish Journal of Nephrology’ Like it has been published in reputed journals.

How will patients get the benefit of this research?

Pro. Parimal Das said that the identification of these new DNA variants will allow the genetic predisposition of the disease to be precisely defined. Its biggest benefits are as follows:

Perfect matching of kidney donor: Genetic mapping will help in finding the genetically most suitable kidney donor, which will increase the chances of successful transplant.

Initial risk assessment: In families where there is a history of PKD, children or young people at risk may be detected before the disease starts.

Personalized Medicine: This research will help in developing different and precise treatments in future based on the DNA profile of each patient.

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Know these important preventive measures

According to researchers, symptoms of PKD often do not become apparent until ages 30 to 40. However, its severity can be reduced with the right lifestyle. Experts recommend that:

• Drink at least 3 to 4 liters of water throughout the day and avoid caffeine (tea-coffee).
• Keep blood pressure under control and get any infection treated immediately.
• Quit smoking, reduce salt intake and exercise regularly.
• Avoid contact sports that can cause kidney injury.

This research has brought a great hope not only for the department of Nephrology in Banaras but also for the entire world. Now through genetic testing it will be possible to control this serious kidney disease in time.