The New York Knicks take on the Philadelphia 76ers in a key Atlantic Division matchup on Wednesday. New York is coming off a 137-134 overtime loss to the Indiana Pacers on Tuesday, while Philadelphia dropped a 135-118 decision at Portland on Monday. The Knicks (34-20), who are second in the Atlantic, are 12-13 on the road this season. The 76ers (30-23), who are fourth in the division, are 15-13 on their home floor. Paul George (suspension) remains out for Philadelphia, while Joel Embiid (knee) is questionable. OG Anunoby (toe) is out for New York.
Tipoff from Xfinity Mobile Arena in Philadelphia is set for 7:30 p.m. ET. Philadelphia is a 2.5-point favorite in the latest Knicks vs. 76ers odds from DraftKings Sportsbook, while the over/under for total points scored is 224.5. Before making any Knicks vs. 76ers picks
The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model enters Week 16 of the 2025-26 NBA season on a sizzling 38-16 roll on top-rated NBA spread picks dating back to last season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen huge returns.
Now, the model has simulated Knicks vs. 76ers 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model’s picks. Here are several NBA odds and NBA betting lines for Sixers vs. Knicks:
| Knicks vs. 76ers spread: | Philadelphia -2.5 at DraftKings |
| Knicks vs. 76ers over/under: | 224.5 points |
| Knicks vs. 76ers money line: | Philadelphia -135, New York +113 |
| Knicks vs. 76ers picks: | See picks at SportsLine |
| Knicks vs. 76ers streaming: | Fubo (Try for free) |
How to make Knicks vs. 76ers picks
After 10,000 simulations of Knicks vs. 76ers, SportsLine’s model is going Over on the total (221.5). The Over has hit in three of the last five New York games, and in three of the last six Philadelphia games.
The SportsLine model is projecting New York’s Jalen Brunson to score 26 points on average and be one of five Knicks players to score 11.6 or more points. Embiid, meanwhile, is projected to have 28 points as four 76ers players score 13.6 points or more.
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