NEW DELHI New Delhi: Men with risk factors for heart disease such as type 2 diabetes, obesity, high blood pressure and smoking may decline in brain health, leading to dementia 10 years earlier than women, a study found on Wednesday. Has gone.
The findings of a long-term study published online in the Journal of Neurology Neurosurgery & Psychiatry have shown that the onset of dementia may occur a decade earlier in men at risk for heart disease – from their mid-50s to mid-70s – Compared to similarly affected women who are most susceptible in their mid-60s to mid-70s.
Researchers at Imperial College London, UK, found that the most vulnerable areas of the brain are those involved in processing auditory information, aspects of visual perception, emotional processing and memory. They noted that the harmful effects were just as pronounced in people who did not have the high-risk APOE4 gene — a genetic risk factor for Alzheimer's disease — as in those who did.
“The detrimental effects of cardiovascular risk were widespread across cortical regions, highlighting how cardiovascular risk can impair a range of cognitive functions,” the researchers said. The study included 34,425 participants from the UK Biobank. All of whom had undergone scans of both their stomach and brain. Their average age was 63 years, but ranged from 45 to 82 years.
The results showed that both men and women with increased levels of abdominal fat and visceral adipose tissue had less brain gray matter volume. The researchers said that higher cardiovascular risk and obesity may lead to increased brain volume over several decades. The team thus emphasized the need to target “modifiable cardiovascular risk factors, including obesity” to treat or prevent neurodegenerative diseases such as Alzheimer's.
The study also emphasizes “the importance of aggressively targeting cardiovascular risk factors before age 55 to prevent neurodegeneration and Alzheimer's disease.” These may lead to other cardiovascular events, such as myocardial infarction. [दिल का दौरा] Although this study is observational and no firm conclusions can be drawn from it, it may be important to control cardiovascular risk and obesity early.
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