NEW DELHI New Delhi: Have you ever felt disappointed when you regain your lost weight in just a few weeks? Blame it on the ability of fat cells to remember, which is a major contributor to obesity, according to a study. Researchers at ETH Zurich in Switzerland showed that obesity causes specific epigenetic changes in the nuclei of fat cells. They remain the same even after dieting. The team led by Ferdinand von Mayen, professor of nutrition and metabolic epigenetics at the university, found that “fat cells remember the state of being overweight and return to this state more easily.” Can”.
The team first analyzed fat cells from overweight mice and mice that had lost excess weight through diet. Their findings showed that mice with these epigenetic markers regained weight more quickly when They then had access to a high-fat diet. Epigenetic markers play a key role in determining which genes are active in our cells and which are not. The study published in the journal Nature found that this mechanism Also works in the same way.
To find out, the team first analyzed fat tissue biopsies from overweight people who had undergone stomach reduction or gastric bypass surgery. The results were consistent with those in rats. The simplest way to combat this phenomenon, Von Meyn said, is to “avoid being overweight,” especially for children, youth and adults.
Researchers show for the first time that “fat cells contain epigenetic memory of obesity”. However, fat cells may not have this ability, the team said. He said the findings suggest that cells in the brain, blood vessels or other organs may also have the ability to remember and contribute to the effects of obesity – an area that could be explored further.
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